Screening and evaluation of antidiabetic activities of endophytic fungi associated with Etlingera elatior

Abstract. Nurjannah L, Azhari A, Wulandari AP, Amin S, Supratman U. 2023. Screening and evaluation of antidiabetic activities endophytic fungi associated with Etlingera elatior. Biodiversitas 24: 3481-3487. elatior (Jack) R.M.Sm. has been well-documented to have antioxidant properties. Among all medical conditions worldwide, diabetes mellitus is one the leading causes death. Therefore, research on discovery medicines inhibitory ?-glucosidase (an enzyme for degrading complex dietary carbohydrates into sugar in digestive process) urgently needed. This study aims isolate evaluate potential fermentation culture E. inhibit activity ?-glucosidase. The were isolated from various parts A total 29 isolates successfully plant's roots, stems, leaves, flowers. tested their ability bioassays. those isolates, 8 such an enzyme, 2 showed highest activities. Morphotype molecular identification using Internal Transcribed Spacer (ITS) regions ribosomal DNA (rDNA), identified them as Daldinia eschscholtzii CFL 7 Hypoxylon trugodes voucher YMJ 57, IC50 values 738 µg/mL 825 µg/mL, respectively. That indicates that they are potentially used preventing or treating diabetic mellitus.